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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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VIT
vitrin
Chromosome 2 · 2p22.2
NCBI Gene: 5212Ensembl: ENSG00000205221.13HGNC: HGNC:12697UniProt: C9J6F5
15PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
extracellular matrix organizationpositive regulation of cell-substrate adhesionspinal cord developmentinterstitial matrixacute tonsillitismultiple sclerosisalcohol drinkingsquamous cell carcinoma
✦AI Summary

Unable to provide a gene function summary for VIT (vitrin) based on the provided abstracts. The PubMed sources supplied do not contain information about the vitrin protein or its biological functions. The abstracts retrieved discuss vitamin D supplementation in endometriosis, vitamin C bioconjugates in skin, venom immunotherapy (VIT) for Hymenoptera allergies, and vitamin D's role in cancer and immune function—none of which address vitrin's role in extracellular matrix organization, cell adhesion, or spinal cord development as indicated in the UniProt and GO annotations provided. To accurately summarize vitrin's function as a promoter of matrix assembly, regulator of neural stem cell proliferation and differentiation, and its involvement in spinal cord formation, peer-reviewed literature specifically investigating vitrin protein would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
acute tonsillitisOpen Targets
0.31Weak
multiple sclerosisOpen Targets
0.30Weak
alcohol drinkingOpen Targets
0.29Weak
squamous cell carcinomaOpen Targets
0.28Weak
liver diseaseOpen Targets
0.27Weak
diabetes mellitusOpen Targets
0.27Weak
occlusion precerebral arteryOpen Targets
0.24Weak
strokeOpen Targets
0.24Weak
amyotrophic lateral sclerosisOpen Targets
0.06Suggestive
peripheral vascular diseaseOpen Targets
0.05Suggestive
familial amyotrophic lateral sclerosisOpen Targets
0.05Suggestive
craniofacial conodysplasiaOpen Targets
0.05Suggestive
Primary lateral sclerosisOpen Targets
0.04Suggestive
neural tube defects, folate-sensitiveOpen Targets
0.04Suggestive
ossification of the posterior longitudinal ligament of the spineOpen Targets
0.04Suggestive
hereditary neuropathy with liability to pressure palsiesOpen Targets
0.04Suggestive
Autosomal recessive spastic paraplegia type 25Open Targets
0.04Suggestive
hereditary spastic paraplegia 25Open Targets
0.04Suggestive
Tetralogy of FallotOpen Targets
0.04Suggestive
amyotrophic lateral sclerosis type 22Open Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
FAUProtein interaction82%CCDC80Shared pathway67%ECM2Shared pathway50%ADAMTSL5Shared pathway33%COL6A5Shared pathway33%COL24A1Shared pathway33%
Tissue Expression6 tissues
Ovary
100%
Heart
63%
Bone Marrow
4%
Lung
3%
Brain
2%
Liver
0%
Gene Interaction Network
Click a node to explore
VITFAUCCDC80ECM2ADAMTSL5COL6A5COL24A1
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q6UXI7
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.45LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF1.23 [1.04–1.45]
RankingsWhere VIT stands among ~20K protein-coding genes
  • #15,733of 20,598
    Most Researched15
  • #14,886of 17,882
    Most Constrained (LOEUF)1.45
Genes detectedVIT
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Effects of vitamin D supplementation in endometriosis: a systematic review.
PMID: 36578019
Reprod Biol Endocrinol · 2022
1.00
2
Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin.
PMID: 33037252
Sci Rep · 2020
0.90
3
Venom allergen immunotherapy.
PMID: 35818146
Allergy Asthma Proc · 2022
0.80
4
Venom Immunotherapy: Questions and Controversies.
PMID: 31761121
Immunol Allergy Clin North Am · 2020
0.70
5
Vitamin D in cancer chemoprevention.
PMID: 25856702
Pharm Biol · 2015
0.60