VPS50 is a unique subunit of the EARP (endosome-associated recycling protein) complex, a heterotetrameric membrane-tethering protein located at recycling endosomes 1. The EARP complex, which shares three subunits (VPS51, VPS52, VPS53) with the related GARP complex, mediates endocytic recycling by promoting the recycling of internalized transferrin receptors back to the plasma membrane 2. VPS50 is required to tether the EARP complex to recycling endosomes and functions distinctly from retrograde transport pathways 1. Biallelic VPS50 variants cause a severe neurodevelopmental disorder characterized by developmental delay, postnatal microcephaly, corpus callosum hypoplasia, seizures, neonatal cholestasis, and failure to thrive 13. Loss-of-function mutations impair transferrin receptor recycling and destabilize associated EARP subunits 1. Beyond endocytic recycling, VPS50 dysfunction affects hepatocyte polarity, causing mislocalization of bile canalicular proteins to basolateral membranes and abnormal tight junctions 1. Additionally, genetic variants in human VPS50 are associated with depression traits, suggesting roles in hippocampal neural network function 4. The disease, termed GARP/EARP deficiency when involving shared subunits, is potentially fatal in early childhood 3.