WDR62 is a WD40-repeat scaffold protein essential for cerebral cortical development, functioning primarily in neural progenitor cell mitosis and centriole biogenesis. The protein localizes to spindle poles and centrosomes, where it regulates mitotic progression through interactions with Aurora A and components of the centriole duplication machinery 1. WDR62 controls neural stem cell mitosis and intermediate neural/glial progenitor specification, with its function intimately linked to c-Jun N-terminal kinase (JNK) signaling 23. Mechanistically, WDR62 maintains spindle stability and checkpoint control; its depletion causes spindle instability, mitotic arrest, and neural progenitor cell death, directly impairing brain size 1. The protein recruits JNK pathway components to regulate both neurogenesis and germ cell meiosis 3. Biallelic WDR62 mutations cause autosomal recessive primary microcephaly type 2 (MCPH2), characterized by severe congenital microcephaly, cortical malformations, pachygyria, and developmental delay 45. Beyond neurodevelopment, WDR62 mutations associate with primary ovarian insufficiency affecting meiosis 6, and elevated WDR62 expression correlates with poor prognosis in ovarian cancer through cell cycle dysregulation via JNK/MAPK8 signaling 7. WDR62 represents a therapeutic target for microcephaly, infertility, and potentially malignant diseases.