WNT10B is a secreted ligand that specifically activates canonical Wnt/β-catenin signaling, triggering β-catenin/LEF/TCF-mediated transcriptional programs 1. The gene plays critical roles in multiple tissues including bone, immune system, mammary gland, adipose tissue, and skin 1. In bone homeostasis, Runx2 directly regulates Wnt10b expression during osteoblast differentiation and mesenchymal cell commitment 2, while gut microbiota-derived short-chain fatty acids promote Wnt10b production by CD8+ T cells, stimulating bone formation 3. WNT10B regulates hair follicle development and regeneration by promoting dermal papilla formation and controlling hair follicle stem cell fate 4; dermal adipose tissue-secreted HGF upregulates WNT10B in dermal papilla to enhance hair growth and pigmentation 5. Disease associations include split-hand/foot malformation type 6, where WNT10B mutations disrupt Wnt-Bmp-Fgf signaling during limb development 6, and selective tooth agenesis 8. In pathological contexts, WNT10B expression is aberrantly elevated in idiopathic pulmonary fibrosis and osteosarcoma; extracellular vesicle-derived microRNAs targeting WNT10B suppress fibrosis 7, while WNT10B expression distinguishes osteosarcoma subtypes with differential therapeutic responses 8. Prolonged epidermal WNT10B overexpression associates with keratinocyte transformation and skin neoplasms 4.