WNT6 is a secreted Wnt family ligand that activates frizzled receptors to regulate the canonical Wnt/β-catenin signaling pathway 1. As a developmental signaling molecule, WNT6 plays essential roles in embryonic morphogenesis, organ development, and post-natal homeostasis 2. In dental pulp cells, WNT6 promotes migration and differentiation through both c-Jun N-terminal kinase (JNK) and canonical Wnt pathways, upregulating odontogenesis-related genes 3. In hair follicles, dermal adipose tissue-derived HGF stimulates WNT6 expression in dermal papilla cells, enhancing Wnt/β-catenin signaling to promote hair growth and pigmentation 4. Dysregulation of WNT6 has emerged as clinically significant in multiple malignancies 1. In gastric cancer, WNT6 is upregulated by caveolin-1 and chemotherapeutics, promoting resistance to anthracycline drugs through canonical Wnt pathway activation 5. WNT6 is frequently overexpressed in colorectal and other cancers, suggesting roles in carcinogenesis 6. Additionally, disruption of topologically associated domains (TADs) containing the WNT6 locus causes ectopic gene-enhancer rewiring, resulting in limb malformations 7. WNT6 represents a promising therapeutic target and biomarker for cancer diagnosis and precision medicine approaches 1.