WNT11 encodes a ligand for frizzled family receptors that functions as a non-canonical Wnt signaling molecule with critical roles in development and disease 1. During embryonic development, WNT11 is essential for proper left-right axis specification, heart development, and kidney organogenesis, as demonstrated by a homozygous human variant causing situs inversus totalis, complex heart defects, and renal hypodysplasia 2. The protein activates non-canonical pathways including WNT11-FZD7-DAAM1 signaling that regulates Rho-ROCK1/2-Myosin II activity 3. In pathological contexts, WNT11 promotes tissue fibrosis through multiple mechanisms: it activates mechanosensitive Piezo1-mediated pathways leading to CCL24 secretion in skin fibrosis 4, drives cardiac fibrosis via FZD5-EGFR crosstalk under pressure overload 5, and promotes pulmonary arterial fibrosis through smooth muscle cell phenotype transition 6. In cancer, WNT11 contributes to poor prognosis by promoting epithelial-to-mesenchymal transition in ovarian cancer 7, supporting tumor-initiating abilities and amoeboid invasion in melanoma 3, and facilitating immune evasion in liver metastasis by suppressing CD8+ T-cell recruitment and promoting immunosuppressive macrophage polarization 8. These diverse functions establish WNT11 as a key regulator of tissue remodeling, fibrosis, and cancer progression.