The XK gene encodes an X-linked membrane protein that serves as a critical adaptor for intracellular protein interactions and membrane organization. The protein functions primarily by recruiting the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane, facilitating lipid transport and membrane homeostasis. XK localizes to both the endoplasmic reticulum membrane and plasma membrane, where it exhibits protein-macromolecule adaptor activity through direct protein binding interactions. The gene is most notably associated with McLeod syndrome, a rare X-linked disorder characterized by neurological and hematological abnormalities. Additionally, XK mutations are linked to XK aprosencephaly syndrome, a severe developmental disorder featuring absent forebrain structures, preaxial limb defects, and ambiguous genitalia 12. This syndrome may involve DNA repair defects, as evidenced by increased chromosome X in affected individuals 2. The protein's role as a membrane adaptor suggests it is essential for proper cellular membrane dynamics and protein trafficking, with its dysfunction leading to significant developmental and physiological consequences. However, detailed mechanistic studies of XK protein function remain limited in the current literature.