ZCCHC17 is a master regulator of neuronal RNA processing and synaptic gene expression 1. The protein contains a CCHC-type zinc finger domain and functions as an RNA-binding protein that interacts with splicing machinery 23. ZCCHC17 binding partners are enriched for RNA splicing proteins, and its knockdown causes widespread alterations in neuronal mRNA splicing patterns, particularly affecting synaptic genes 34. In Alzheimer's disease (AD) pathogenesis, ZCCHC17 plays a critical protective role. ZCCHC17 protein levels decline early in AD brain tissue, preceding neuronal loss 31. Loss of ZCCHC17 results in reduced expression of synaptic proteins and disrupts the excitation/inhibition balance of neuronal activity, phenocopying AD-related hyperexcitability 5. ZCCHC17 expression correlates with cognitive resilience in AD patients and shows APOE4-dependent negative correlation with tau pathology burden 34. The overlapping splicing changes between ZCCHC17 knockdown and tau overexpression suggest mechanistic links to tau-related pathology 4. Maintenance of ZCCHC17 function is proposed as a therapeutic strategy for preserving cognitive function in AD 3.