ZEB1 (zinc finger E-box binding homeobox 1) is a transcriptional repressor that plays critical roles in epithelial-mesenchymal transition (EMT) and cancer progression 1. ZEB1 functions by binding to E-box sequences in target gene promoters to regulate transcription, with its activity modulated through post-translational modifications including phosphorylation and ubiquitination 2. The protein stabilization is regulated by USP51-mediated deubiquitination and GTSE1 binding to unphosphorylated ZEB1 21. ZEB1 promotes cancer metastasis through multiple mechanisms: it induces metabolic reprogramming by upregulating glycolytic enzymes (HK2, PFKP, PKM2), creating an immunosuppressive tumor microenvironment that promotes M2 macrophage polarization 3. Additionally, ZEB1 remodels the hyaluronan network by regulating ITIH2, HAS2, and CD44 expression, enhancing cancer cell motility and invasiveness 4. In melanoma, ZEB1 controls lineage-specific transcriptional programs essential for cell state transitions between proliferative and invasive phenotypes 5. ZEB1 also regulates cellular processes beyond cancer, including periodontal ligament stem cell differentiation through ROCK1/AMPK signaling 6 and osteosarcoma progression via ferroptosis regulation 7. These findings establish ZEB1 as a key regulator of cellular plasticity and a potential therapeutic target across multiple pathological conditions.