ZFR (zinc finger RNA binding protein) is a multifunctional protein that plays significant roles in cancer development and cellular regulation. The protein functions as an oncogene in multiple cancer types, promoting tumor progression through regulation of cell proliferation, migration, and invasion 1. In pancreatic cancer, ZFR expression is significantly elevated compared to normal tissues, and its knockdown results in decreased cell viability, invasion ability, and G0/G1 cell cycle arrest through modulation of cell cycle regulators including CDK2, CDK4, cyclin A, cyclin D1, and p27 2. ZFR also promotes colorectal and liver cancer development, with overexpression accelerating tumor growth and knockdown decelerating it 1. In diabetic retinopathy, ZFR is upregulated under high glucose conditions and contributes to angiogenesis by promoting proliferation and migration of human retinal microvascular endothelial cells, with its expression regulated by O-glycosylation modifications 3. Additionally, ZFR is subject to negative feedback regulation by its intronic microRNA miR-579, with alternative polyadenylation allowing differential targeting of the host gene 4. The protein also interacts with the androgen receptor through its zinc finger region, contributing to transcriptional regulation 5. Clinically, ZFR represents a potential therapeutic target across multiple cancer types due to its oncogenic properties.