ZG16B (zymogen granule protein 16B) is a secretory lectin-like glycoprotein with dual roles in oral homeostasis and cancer progression 1. Structurally, it contains a jacalin-related lectin domain with a β-prism fold that enables glycan binding 2. In oral health, ZG16B functions as a microbial glycan probe, selectively binding commensal dental plaque bacteria such as Streptococcus vestibularis through cell wall polysaccharides 3. It regulates commensal growth via a mucin-assisted clearance mechanism involving salivary MUC7, maintaining oral microbiome homeostasis 3. In cancer, ZG16B promotes tumor progression through multiple pathways: it enhances pancreatic cancer cell migration and invasion via the TLR4/MyD88/NF-κB signaling pathway 1, promotes angiogenesis, increases vascular permeability, and modulates the tumor microenvironment by enhancing myeloid-derived suppressor cells and M2 macrophages 1. ZG16B is significantly upregulated in pancreatic, ovarian, colorectal, gastric, and breast cancers, correlating with disease prognosis 14. Clinically, reduced salivary ZG16B expression serves as a biomarker for chr16 graft-versus-host disease affecting salivary glands 5. Therapeutic strategies targeting ZG16B, including monoclonal antibodies like the investigational PBP1510, show promise in clinical trials for advanced pancreatic cancer 1.