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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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ZMIZ2
zinc finger MIZ-type containing 2
Chromosome 7 Β· 7p13
NCBI Gene: 83637Ensembl: ENSG00000122515.16HGNC: HGNC:22229UniProt: E7EWM3
47PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
positive regulation of transcription by RNA polymerase IIprotein bindingnucleoplasmnucleusAbnormality of the skeletal systemintelligenceobesityattention deficit hyperactivity disorder
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

zinc finger MIZ-type containing 2

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
Abnormality of the skeletal systemOpen Targets
0.50Moderate
intelligenceOpen Targets
0.47Moderate
obesityOpen Targets
0.31Weak
attention deficit hyperactivity disorderOpen Targets
0.30Weak
autism spectrum disorderOpen Targets
0.30Weak
smoking cessationOpen Targets
0.21Weak
thyroiditisOpen Targets
0.15Weak
triple-negative breast cancerOpen Targets
0.09Suggestive
hepatocellular carcinomaOpen Targets
0.08Suggestive
posterior cortical atrophyOpen Targets
0.07Suggestive
neoplasmOpen Targets
0.07Suggestive
major depressive disorderOpen Targets
0.06Suggestive
non-small cell lung carcinomaOpen Targets
0.06Suggestive
lung cancerOpen Targets
0.06Suggestive
breast cancerOpen Targets
0.04Suggestive
agingOpen Targets
0.03Suggestive
cancerOpen Targets
0.02Suggestive
lung adenocarcinomaOpen Targets
0.02Suggestive
clonal hematopoiesisOpen Targets
0.02Suggestive
ovarian cancerOpen Targets
0.02Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
SMARCE1Protein interaction82%SMARCA4Protein interaction71%ZMIZ1Shared pathway50%NFATC2IPShared pathway33%KIAA1586Shared pathway33%WFIKKN2Shared pathway25%
Tissue Expression6 tissues
Lung
100%
Ovary
90%
Brain
72%
Liver
71%
Bone Marrow
69%
Heart
46%
Gene Interaction Network
Click a node to explore
ZMIZ2SMARCE1SMARCA4ZMIZ1NFATC2IPKIAA1586WFIKKN2
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q8NF64
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
0.40Moderately Constrained
pLIβ“˜
1.00Intolerant
Observed/Expected LoF0.29 [0.21–0.40]
RankingsWhere ZMIZ2 stands among ~20K protein-coding genes
  • #9,291of 20,598
    Most Researched47
  • #1,990of 17,882
    Most Constrained (LOEUF)0.40 Β· top quartile
Genes detectedZMIZ2
Sources retrieved0 papers
Response timeβ€”