ZNF135 is a zinc finger protein that functions as a transcriptional repressor involved in regulating cell morphology and cytoskeletal organization 1. The protein contains DNA-binding domains and exhibits RNA polymerase II-specific transcription factor activity, localizing to the nucleus where it regulates transcription [GO annotations]. ZNF135 is expressed in human brain tissue and plays a role in neurological development, as demonstrated by a patient with homozygous ZNF135 mutations presenting with neurological and developmental symptoms 1. Beyond neurological function, ZNF135 shows clinical relevance in cancer biology. The gene is hypermethylated in colorectal cancer progression, particularly at stage IV, suggesting epigenetic silencing contributes to tumorigenesis 2. In esophageal adenocarcinoma, ZNF135 is downregulated through miRNA-mediated mechanisms and DNA hypermethylation, making it a potential diagnostic biomarker 3. ZNF135 has been identified as the optimal gene in cervical cancer epidermis development pathways 4. Recent evidence indicates reduced ZNF135 expression in schizophrenia leads to derepression of enhancer RNAs and disrupted neuronal differentiation, linking the protein to psychiatric disease risk 5. ZNF135 also serves as a transcription factor regulating genes involved in esophageal cancer progression 6.