ZNF141 is a C2-H2/KRAB zinc finger transcription factor located on chromosome 4.3 that functions as a transcriptional repressor involved in limb development 1. The protein contains DNA-binding domains that enable sequence-specific binding to RNA polymerase II cis-regulatory regions, allowing regulation of transcription and anatomical structure morphogenesis 2. ZNF141 mutations cause non-syndromic postaxial polydactyly, a common inherited limb abnormality characterized by supernumerary digits. Both autosomal recessive and dominant inheritance patterns have been documented, with identified mutations including missense variants (c.1420C>T; p.Thr474Ile) that disrupt normal limb anterior-posterior axis patterning 3245. ZNF141 is one of seven genes implicated in postaxial polydactyly pathogenesis 4. Beyond developmental roles, ZNF141 demonstrates clinical significance in malignancy. Expression analysis in soft tissue sarcomas identified ZNF141 as a component of prognostic models for overall and progression-free survival, with functional studies demonstrating that ZNF141 promotes sarcoma cell proliferation and viability 6. Additionally, ZNF141 shows differential expression in extranodal NK/T-cell lymphoma, where it is upregulated in affected patients 7. These findings suggest ZNF141 functions as both a developmental regulator and potential oncogenic factor.