ZNF174 is a transcriptional repressor protein belonging to the C2H2-type zinc-finger family, characterized by three zinc fingers positioned at its carboxyl terminus and a novel 65-amino acid finger-associated SCAN box near the amino terminus 1. The SCAN domain functions as a conserved oligomerization motif that mediates homodimerization and heterodimerization with other SCAN domain-containing proteins, enabling selective partner choice in transcription factor complex assembly 23. Structurally, the SCAN dimer adopts a domain-swapped configuration with approximately 42% alpha-helical content and remarkable thermal stability 24. ZNF174 selectively represses transcription driven by growth-regulatory promoters, including platelet-derived growth factor-B chain and transforming growth factor-beta 1, demonstrating sequence-specific DNA binding capacity 1. The gene is located on chromosome 16.3 and is expressed broadly across human tissues, with highest expression in adult testis and ovary 1. As a nuclear transcription factor regulating RNA polymerase II-mediated transcription, ZNF174 represents a member of a newly defined subclass of vertebrate-specific zinc-finger proteins that utilize the SCAN domain for oligomerization-dependent transcriptional regulation.