ZNF214 is a zinc finger protein located on chromosome 11 that functions as a DNA-binding transcription factor 1. The gene is predominantly expressed in testicular tissue and plays a role in spermatogenesis and testicular descent 2. ZNF214 exhibits tissue-specific imprinting patterns and exists in close genomic proximity to the related ZNF215 gene, with portions of ZNF215 transcripts derived from the antisense strand of ZNF214 3. Mutations and polymorphisms in ZNF214 are associated with male factor subfertility, particularly in cases of idiopathic impaired spermatogenesis and cryptorchidism 2. Five novel variants were identified in subfertile patients, with at least three inherited maternally 2. Common polymorphisms in ZNF214 contribute as risk factors for isolated cryptorchidism 4. Additionally, CNV-associated reduced transcript expression of ZNF214 has been identified in autism spectrum disorder, suggesting neurodevelopmental involvement 5. Duplications of the 11p15.4 region encompassing ZNF214 cause a novel microduplication syndrome featuring intellectual disability, obesity, and dysmorphic features 1. These findings implicate ZNF214 in reproductive development, spermatogenesis, and neurodevelopmental processes through transcriptional regulation mechanisms.