ZNF266 is a C2H2-type zinc finger transcription factor that functions as a nuclear protein with DNA-binding and transcriptional regulatory activity 1. The protein contains a trans-activation domain in its non-zinc finger region and three nuclear localization signals within the zinc finger domains 2. In lung adenocarcinoma, ZNF266 acts as a tumor suppressor by binding to the CA9 gene promoter and suppressing its transcription 3. This transcriptional repression reduces intracellular pH and inhibits mTOR signaling, thereby suppressing cancer cell proliferation, migration, and invasion 3. Patients with low ZNF266 expression demonstrate poorer prognosis, and adeno-associated virus-mediated ZNF266 overexpression significantly inhibited tumor growth in patient-derived xenograft models 3. ZNF266 has also been identified as a somatic mutation target in tongue squamous cell carcinoma, with evidence suggesting it promotes malignancy in this context 4. Additionally, related zinc finger proteins in the same family regulate hematopoietic differentiation and cell proliferation through interactions with key signaling molecules 5 6. ZNF266 represents a therapeutic target for cancer treatment, particularly in lung adenocarcinoma.