ZNF268 is a KRAB-containing C2H2 zinc finger protein involved in early human embryonic development and hematopoiesis 1. The protein contains 24 C-terminal zinc fingers and an N-terminal KRAB domain that facilitate nuclear localization through cooperative interaction with KAP1 2. ZNF268 expression is developmentally regulated, predominantly expressed in early embryos and fetal liver 3, with transcription controlled by an atypical intragenic promoter requiring CREB-binding elements 4. Functionally, ZNF268 acts as a transcriptional regulator and is transcriptionally repressed by GATA-1 during erythropoiesis 5. Aberrant alternative splicing of ZNF268 is associated with hematological malignancies, with specific splice variants significantly elevated in leukemia patients compared to healthy donors 6. In cervical cancer, ZNF268 overexpression promotes tumorigenesis by enhancing NF-κB signaling, driving cell proliferation and inhibiting apoptosis 7. Knockdown of ZNF268 suppresses cancer cell growth, induces G0/G1 cell cycle arrest, and increases sensitivity to apoptotic stimuli. These findings establish ZNF268 as a developmentally important regulator with significant roles in malignant transformation and potential prognostic value in cancer diagnostics.