ZNF318 is a zinc finger transcriptional regulator located on chromosome 6 with multiple biological roles. It functions as a transcriptional coactivator for androgen receptor (AR)-mediated transactivation and may regulate transcription during spermatogenesis, particularly during meiotic division [UniProt]. ZNF318 exhibits both positive and negative regulation of DNA-templated transcription and possesses protein homodimerization activity, functioning in the nucleoplasm [GO Annotations]. The protein serves as a substrate for histone deacetylase 8 (HDAC8), suggesting post-translational regulation through acetylation 1. Clinically, ZNF318 mutations are emerging as novel drivers of clonal hematopoiesis (CH), with mutant clones expanding in frequency and size with age, comparable to established CH drivers 23. ZNF318 has also been identified as a novel candidate gene for male infertility, with strong biological relevance to human spermatogenesis 4. Additionally, DNA methylation changes near the ZNF318 gene (cg10816169) are associated with increased breast cancer risk in epigenetic studies 5. These findings position ZNF318 as a multifunctional regulator with significance in aging-related hematologic disease, reproductive biology, and cancer susceptibility.