ZNF365 is a zinc finger protein with dual roles in neurodevelopment and genomic stability. In the nervous system, ZNF365 negatively regulates neurite outgrowth and controls neurogenesis, including basket cell morphogenesis and oligodendrocyte differentiation [UniProt annotations]. In DNA repair, ZNF365 is required for homologous recombination-mediated resolution of double-strand breaks and recovery of stalled replication forks, contributing to genomic stability and telomere maintenance through PARP1 and MRE11 interactions [UniProt annotations]. Clinically, ZNF365 variants are associated with multiple inflammatory and genetic diseases. Polymorphisms in ZNF365 are linked to increased susceptibility to inflammatory bowel disease, with rs10761659 showing protective effects against Crohn's disease and ulcerative colitis 1, and rs10995251 associated with childhood bronchial asthma with elevated serum IgE levels 2. ZNF365 variants also associate with uveitis 3 and idiopathic achalasia, though the underlying mechanism remains unclear 4. Additionally, ZNF365 variants correlate with mammographic breast density and breast cancer risk 5. ZNF365 expression is reduced in chr10 rhinosinusitis with nasal polyps, where its loss impairs epithelial proliferation and defense against Staphylococcus aureus 6. In pulmonary fibrosis, ZNF365 is upregulated and protective; its absence accelerates lung fibrosis through increased cellular senescence 7.