DISC1 is a multifunctional scaffold protein essential for neuronal development and brain function. Primarily, DISC1 regulates neural progenitor proliferation in the embryonic ventricle/subventricular zone and adult hippocampal dentate gyrus through modulation of Wnt-mediated signaling and GSK3B/CTNNB1 activity 1. It controls neurogenesis tempo by inhibiting AKT-mTOR signaling through interaction with CCDC88A and facilitates granule cell precursor migration during hippocampal development 2. DISC1 also participates in microtubule network organization via interaction with PCNT and functions as a core component of the human oocyte microtubule organizing center during meiotic spindle assembly 34. Additionally, DISC1 activates autophagy via AMPK-mTOR signaling, providing neuroprotection against viral infection and developmental insult 5. DISC1 is a major susceptibility gene for schizophrenia and affective disorders 67. DISC1 variants associate with working memory deficits and altered prefrontal-hippocampal brain activity in schizophrenia patients 8. Pathogenic DISC1-Δ3 variant in oligodendrocyte precursor cells drives schizophrenia-like phenotypes through aberrant Wnt/β-catenin pathway activation and synaptic disruption 9. Common variants show inconsistent associations with structural brain changes across imaging studies 1011.