ZNF385A (zinc finger protein 385A) is an RNA-binding protein with multifaceted roles in cellular regulation and disease pathogenesis. As a dsRNA-binding protein, ZNF385A regulates cellular dsRNA homeostasis, with knockout cells showing elevated endogenous dsRNA levels and enhanced interferon-β transcription 1. The protein functions as a post-transcriptional regulator, binding 3'-UTR sequences of target mRNAs to modulate their translation and localization, though specific mechanistic details remain incompletely characterized in the provided literature. ZNF385A exhibits oncogenic properties across multiple cancer types. In colorectal cancer, ZNF385A knockdown suppresses cell proliferation, migration, invasion, and ROS production 2. In hepatocellular carcinoma, elevated ZNF385A expression correlates with poor prognosis and immune suppression, with HBV infection potentially driving overexpression 3. In cervical cancer, ZNF385A functions as a direct miR-138-5p target that promotes proliferation and cell cycle progression through the SFN/FAS signaling axis 4. ZNF385A plays a critical role in DNA damage response, with increased expression following Cr(VI)-induced DNA damage and involvement in ribosomal DNA copy number variations 5. Beyond cancer, ZNF385A shows associations with allergic diseases as a potential methylation biomarker 6 and emerges as a hub gene in sleep disorders pathogenesis 7. These findings suggest ZNF385A represents a promising therapeutic target across multiple disease contexts.