ZNF444 is a zinc finger transcription factor that functions as a sequence-specific DNA-binding regulator of RNA polymerase II transcription 1. It localizes to the nucleoplasm and nucleolus, where it binds to cis-regulatory regions including the SCARF1 promoter 1. ZNF444 is part of a regulatory network controlling the chromosome 19 microRNA cluster (C19MC) promoter, working alongside other transcription factors including NR2F6, SREBF1, TBP, GATA3, GABPB1, and ETV4 1. In disease contexts, ZNF444 is notably involved in myoepithelial tumors through EWSR1 fusion events. The novel EWSR1-ZNF444 fusion gene was identified in soft tissue myoepithelial carcinoma 2, and ZNF444 serves as a confirmed fusion partner in myoepithelial tumors affecting skin, bone, and soft tissue 3. ZNF444 rearrangements have also been detected in primary pulmonary myoepithelial carcinomas 4. Clinically, ZNF444 overexpression is observed in bladder cancer patients and correlates with C19MC upregulation, suggesting potential roles in oncogenic microRNA regulation 1. The gene was excluded as a candidate in Peutz-Jeghers syndrome genetic studies 5, indicating it does not harbor pathogenic germline mutations in that disorder.