ZNF502 is a zinc finger protein functioning as a transcriptional regulator with RNA polymerase II-specific DNA-binding activity 1. In oral squamous cell carcinoma, ZNF502 binds to the lncRNA ENAH-202 and facilitates Vimentin (VIM) transcription, promoting epithelial-to-mesenchymal transition, cell proliferation, migration, and metastasis 1. ZNF502 emerges as a prognostic biomarker in esophageal cancer; it is one of six zinc finger family genes in a model that independently predicts overall survival and correlates with immune cell infiltration and chemotherapy sensitivity 2. In acute myeloid leukemia, ZNF502 is upregulated alongside other favorable prognostic signatures in cytogenetically normal cases associated with longer overall and event-free survival 3. ZNF502 is implicated in psychiatric disease risk; it shows transcriptome-wide significant associations with depression through altered brain expression in the dorsolateral prefrontal cortex 4, and gene expression changes in ZNF502 are associated with suicide risk 5. Additionally, ZNF502 interacts with the respiratory syncytial virus matrix protein; knockdown of ZNF502 reduces RSV replication, implicating it in viral life cycle regulation 6.