ZNF675 is a primate-specific Krüppel-associated box zinc finger (KZNF) transcriptional repressor that emerged during primate evolution and plays critical roles in neurodevelopment and early embryogenesis. ZNF675 functions as a DNA-binding transcription factor with zinc ion binding capacity 1. Mechanistically, ZNF675 interferes with HES1 auto-inhibition, a process essential for neural progenitor maintenance, and regulates promoters of neurodevelopmental genes including HES1, microcephalin 1, and sestrin 3 1. ZNF675 demonstrates paternal-specific expression and initiates human zygotic genome activation at the 8-cell stage, a process unique to primates 2. During early embryo development, ZNF675 shows significant overexpression in androgenotes compared to biparental embryos, highlighting its role in paternal genome contributions 3. The gene negatively regulates multiple signaling pathways including NF-κB, TNF-mediated, IL-1-mediated signaling, and osteoclast differentiation 4. Disease relevance includes association with neurodevelopmental disorders through copy number variations at 19p12 1, moderate chr19 periodontitis susceptibility 5, and infant attachment disorganization 6. These findings establish ZNF675 as an important factor integrating into preexisting gene regulatory networks during human development.