1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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7PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLETranscription Factor
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
RNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA-binding transcription factor activityubiquitin-protein transferase activityprotein polyubiquitinationtype 2 diabetes mellitusdiabetes mellitusPainBlackfan-Diamond anemia
Based on limited published evidence, ZNF738 is a zinc finger protein predicted to function as a DNA-binding transcription factor involved in transcriptional regulation. GO annotations indicate it possesses DNA-binding transcription factor activity and ubiquitin-protein transferase activity, with roles in regulating DNA-templated transcription and protein polyubiquitination. ZNF738 localizes to the nucleus and binds RNA polymerase II cis-regulatory regions. In hepatocellular carcinoma, ZNF738 expression is upregulated and associated with altered three-dimensional chr19 architecture 1, suggesting involvement in cancer-related transcriptional dysregulation.
1
ZNF738 is upregulated in hepatocellular carcinoma and associated with altered 3D chromatin architecture and interchromosomal interactions
PMID: 37925679⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
type 2 diabetes mellitusOpen Targets
diabetes mellitusOpen Targets
Blackfan-Diamond anemiaOpen Targets
22q11.2 deletion syndromeOpen Targets
X-linked severe congenital neutropeniaOpen Targets
neutropenia, severe congenital, 2, autosomal dominantOpen Targets
WHIM syndrome 2Open Targets
reticular dysgenesisOpen Targets
nonimmune chronic idiopathic neutropenia of adultsOpen Targets
autosomal recessive severe congenital neutropenia due to CSF3R deficiencyOpen Targets
combined immunodeficiency due to moesin deficiencyOpen Targets
neutropenia, severe congenital, 1, autosomal dominantOpen Targets
pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9Open Targets
combined immunodeficiency with skin granulomasOpen Targets
X-linked sideroblastic anemia 1Open Targets
chronic myelogenous leukemiaOpen Targets
neutropenia, severe congenital, 10, autosomal recessiveOpen Targets
medulloblastomaOpen Targets
oligodendrogliomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.