Based on limited published evidence, ZNF738 is a zinc finger protein predicted to function as a DNA-binding transcription factor involved in transcriptional regulation. GO annotations indicate it possesses DNA-binding transcription factor activity and ubiquitin-protein transferase activity, with roles in regulating DNA-templated transcription and protein polyubiquitination. ZNF738 localizes to the nucleus and binds RNA polymerase II cis-regulatory regions. In hepatocellular carcinoma, ZNF738 expression is upregulated and associated with altered three-dimensional chr19 architecture 1, suggesting involvement in cancer-related transcriptional dysregulation.