DZIP3 (DAZ interacting zinc finger protein 3) is an RNA-binding RING-type E3 ubiquitin ligase that regulates protein stability through both ubiquitination and RNA interactions 12. The protein functions through a unique dual mechanism: it uses its lysine-rich region to bind and stabilize target mRNAs, while its RING domain mediates protein ubiquitination 2. DZIP3 can promote both protein degradation (K48-linked ubiquitination) and stabilization (K63-linked ubiquitination) depending on the substrate 32. A key function involves stabilizing Cyclin D1 at both mRNA and protein levels in a cell cycle-dependent manner, promoting G1/S transition and cell proliferation 2. DZIP3 serves as a transcriptional coactivator, particularly for estrogen receptor-α, enhancing target gene expression 4. In cancer contexts, DZIP3 shows complex roles: it promotes proliferation and metastasis in gastric cancer 5 and facilitates immune evasion in MASH-HCC by regulating OCTN2 stability 6, while paradoxically serving as a favorable prognostic marker in gliomas 7. The protein also functions in innate immunity, where it degrades the antiviral factor GBP5 during RSV infection 3.