ZNF76 is a sequence-specific DNA-binding transcription factor that regulates genes transcribed by both RNA polymerase II and III 1. It recognizes the Staf-binding site (SBS) motif and activates expression of small nuclear RNAs (snRNAs) and mRNAs 1. ZNF76 also functions as a transcriptional repressor by inhibiting TATA-binding protein (TBP) activity, with this repression regulated by acetylation, sumoylation, and alternative splicing 2. Clinically, reduced ZNF76 expression associates with platinum chemotherapy resistance and poor survival in ovarian cancer patients, suggesting prognostic value as a biomarker 3. Additionally, the ZNF76 rs10947540 polymorphism is a genetic susceptibility factor for systemic lupus erythematosus (SLE), with the C allele increasing SLE risk and correlating with elevated serum creatinine levels 4. Recent evidence indicates ZNF76 functions as a transcription factor for DRP1, where succinylation-mediated activation of ZNF76 by high glucose promotes mitophagy and accelerates T cell aging in rheumatoid arthritis 5. Together, these findings establish ZNF76 as a multifunctional transcriptional regulator with significant roles in cancer chemoresistance and autoimmune disease pathogenesis.