2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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15PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLEHighly ConstrainedTranscription Factor
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
nucleusnegative regulation of cell population proliferationnegative regulation of DNA-templated transcriptionprotein bindingneurodegenerative diseasetype 2 diabetes mellitusmetabolic syndromehypertension
Based on limited published evidence, ZNF777 is a KRAB zinc finger transcription factor that functions as a transcriptional repressor 1. It localizes to the nucleus and contains a conserved DUF3669 domain that mediates protein-protein oligomerization and contributes to transcriptional repression activity 1. ZNF777 inhibits cell proliferation at low cell density through zinc finger domain-dependent down-regulation of NIBAN1/FAM129A, leading to p21 induction 2. Its repressor activity depends on intact DUF3669 and variant KRAB domain configuration rather than canonical KRAB-TRIM28 interactions 1.
1
DUF3669 domain in ZNF777 mediates oligomerization and contributes to transcriptional repression; repressor activity depends on intact DUF3669 and variant KRAB domain configuration
PMID: 318567082
ZNF777 inhibits cell proliferation at low cell density through down-regulation of FAM129A and induction of p21 in a zinc finger domain-dependent manner
PMID: 25560148⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
neurodegenerative diseaseOpen Targets
type 2 diabetes mellitusOpen Targets
metabolic syndromeOpen Targets
perinatal diseaseOpen Targets
acquired thrombocytopeniaOpen Targets
ovarian neoplasmOpen Targets
multiple sclerosisOpen Targets
diabetes mellitusOpen Targets
ovarian dysfunctionOpen Targets
cardiomyopathyOpen Targets
cervical carcinomaOpen Targets
breast cancerOpen Targets
colorectal cancerOpen Targets
leiomyosarcomaOpen Targets
lung adenocarcinomaOpen Targets
prostate cancerOpen Targets
urinary bladder carcinomaOpen Targets
urinary bladder cancerOpen Targets
No pathogenic variants reported on ClinVar for this gene.