1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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15PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLETranscription Factor
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingnucleusDNA-binding transcription factor activityRNA polymerase II cis-regulatory region sequence-specific DNA bindingovarian neoplasmpancreatic adenocarcinomasevere acute respiratory syndromeCOVID-19
ZNF783 encodes a zinc finger protein likely involved in transcriptional regulation through DNA binding. Based on limited published evidence, ZNF783 functions as a DNA-binding transcription factor that binds RNA polymerase II cis-regulatory regions and regulates DNA-templated transcription in the nucleus. ZNF783 was identified as a top candidate gene frequently methylated in prostate cancer and high-grade prostatic intraepithelial neoplasia, with methylation associated with gene expression inactivation in prostate cancer cell lines 1.
1
ZNF783 identified as a top candidate novel gene frequently methylated in prostate cancer and high-grade prostatic intraepithelial neoplasia, with methylation associated with inactivation of gene expression in PCa cell lines
PMID: 23896626⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
ovarian neoplasmOpen Targets
pancreatic adenocarcinomaOpen Targets
severe acute respiratory syndromeOpen Targets
Abnormal nasolacrimal system morphologyOpen Targets
hepatocellular carcinomaOpen Targets
multiminicore myopathyOpen Targets
posterior cortical atrophyOpen Targets
gastric cancerOpen Targets
head and neck squamous cell carcinomaOpen Targets
nonpapillary renal cell carcinomaOpen Targets
ovarian cancerOpen Targets
ovarian serous cystadenocarcinomaOpen Targets
thyroid cancer, nonmedullary, 1Open Targets
urinary bladder cancerOpen Targets
urinary bladder carcinomaOpen Targets
Uveal MelanomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.