ZNF212 is a zinc finger transcription factor with dual roles in gene regulation and DNA damage repair. As a transcriptional regulator, ZNF212 functions as a DNA-binding transcription activator that positively regulates RNA polymerase II-dependent transcription 1. The protein recognizes the TATTTC sequence motif in gene promoters and directly regulates phospholipase D3 (PLD3) expression, which is critical for cerebellar Purkinje cell survival 1. Beyond transcriptional roles, ZNF212 functions in genomic integrity maintenance through direct interaction with TRAIP, a key DNA damage response factor 2. ZNF212 colocalizes with DNA damage sites and is essential for homologous recombination-mediated repair and interstrand crosslink repair, where it promotes NEIL3 recruitment 2. Clinically, ZNF212 dysregulation is associated with Barrett's esophagus-related adenocarcinoma, where it is consistently upregulated in tumor tissues 3. Loss of ZNF212 in mice causes Purkinje cell degeneration, cerebellar atrophy, and locomotive abnormalities 1, while restoration of ZNF212 prevents neurodegeneration, suggesting therapeutic potential in neurodegenerative conditions. The ZNF212-PLD3 axis is relevant to alcohol-induced cerebellar degeneration 1.