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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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ZNG1C
Zn regulated GTPase metalloprotein activator 1C
Chromosome 9 Β· 9q21.11
NCBI Gene: 445571Ensembl: ENSG00000196873.17HGNC: HGNC:18519UniProt: Q5JTY5
18PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingzinc ion bindingzinc chaperone activityprotein maturationcongenital hydronephrosisureter cancerureteral neoplasmureterocele
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

Zn regulated GTPase metalloprotein activator 1C

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
congenital hydronephrosisOpen Targets
0.07Suggestive
ureter cancerOpen Targets
0.07Suggestive
ureteral neoplasmOpen Targets
0.07Suggestive
ureteroceleOpen Targets
0.07Suggestive
Genetic renal or urinary tract malformationOpen Targets
0.07Suggestive
familial vesicoureteral refluxOpen Targets
0.07Suggestive
congenital primary megaureterOpen Targets
0.06Suggestive
Ochoa syndromeOpen Targets
0.06Suggestive
vesicoureteral reflux 3Open Targets
0.06Suggestive
renal hypodysplasia/aplasia 3Open Targets
0.06Suggestive
congenital anomalies of kidney and urinary tract 1Open Targets
0.05Suggestive
caudal duplicationOpen Targets
0.05Suggestive
renal dysplasiaOpen Targets
0.05Suggestive
primary hyperoxaluria type 2Open Targets
0.05Suggestive
urofacial syndrome 2Open Targets
0.05Suggestive
renal hypoplasiaOpen Targets
0.05Suggestive
thymic-renal-anal-lung dysplasiaOpen Targets
0.05Suggestive
atresia of urethraOpen Targets
0.05Suggestive
adenine phosphoribosyltransferase deficiencyOpen Targets
0.05Suggestive
nephrolithiasis susceptibility caused by SLC26A1Open Targets
0.05Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
NAA10Shared pathway100%YAE1Shared pathway100%NAA16Shared pathway100%NAA15Shared pathway100%LMF2Shared pathway100%CHCHD4Shared pathway100%
Tissue Expression6 tissues
Liver
100%
Ovary
89%
Brain
69%
Lung
63%
Bone Marrow
39%
Heart
0%
Gene Interaction Network
Click a node to explore
ZNG1CNAA10YAE1NAA16NAA15LMF2CHCHD4
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q5JTY5
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.08LoF Tolerant
pLIβ“˜
0.63Intermediate
Observed/Expected LoF0.00 [0.00–1.08]
RankingsWhere ZNG1C stands among ~20K protein-coding genes
  • #14,902of 20,598
    Most Researched18
  • #10,938of 17,882
    Most Constrained (LOEUF)1.08
Genes detectedZNG1C
Sources retrieved0 papers
Response timeβ€”