ZSCAN10 is a zinc finger transcription factor that plays critical roles in pluripotent stem cell maintenance and cellular reprogramming. It functions as an embryonic stem cell-specific transcription factor required to maintain pluripotency, with the ability to both activate and repress target gene expression in a context-dependent manner 1. ZSCAN10 serves as a highly sensitive marker for detecting residual undifferentiated iPSCs in cell therapy products, with detection limits as low as 0.0001-0.01% of cells 234. During cellular reprogramming of aged donors, ZSCAN10 expression is crucial for correcting genomic instability by normalizing ROS-glutathione homeostasis and restoring proper DNA damage responses 5. Clinically, bi-allelic loss-of-function variants in ZSCAN10 cause a novel neurodevelopmental disorder characterized by global developmental delay, facial asymmetry, outer ear malformations, and sensorineural hearing loss with semicircular canal dysplasia 1. The protein specifically binds DNA consensus sequences and regulates key pluripotency genes including POU5F1/OCT4 and ZSCAN4. ZSCAN10 has also been identified as a potential biomarker in various contexts, including intervertebral disc cells and glioblastoma progression 67.