AAMP (angio-associated migratory cell protein) is a multifunctional protein that plays crucial roles in angiogenesis, cell migration, and cancer progression. Its primary function involves regulating endothelial cell migration and angiogenesis through RhoA/Rho kinase signaling pathways 1. AAMP expression is significantly upregulated by VEGF in a concentration and time-dependent manner, and VEGF recruits AAMP to cell membrane protrusions where it mediates endothelial cell spreading and migration 1. Mechanistically, AAMP interacts with cell division cycle 42 (CDC42) and enhances its activation by impairing the combination of ARHGAP1 and CDC42, resulting in cellular protrusion formation 2. AAMP also regulates the stability and activity of RhoA and RhoB, colocalizing with F-actin and cortactin at membrane ruffles 3. In cancer contexts, AAMP functions as a pro-tumor protein that promotes migration and invasion in non-small cell lung cancer cells 2 and serves as an unfavorable prognostic marker across multiple cancer types 4. AAMP has been identified as a binding partner of the immunosuppressive protein B7-H3 5 and acts as a negative regulator of endothelial barrier function through protein turnover mechanisms controlled by ubiquitination 3.