ABCC10 (ATP-binding cassette subfamily C member 10), also known as multidrug resistance protein 7 (MRP7), is a 171 kDa ATP-dependent transporter localized to the basolateral plasma membrane 1. As a lipophilic anion pump, ABCC10 actively extrudes physiological compounds and xenobiotics, transporting glucuronide conjugates (estradiol-17-beta-O-glucuronide) and glutathione conjugates (leukotriene C4) 1. ABCC10 functions in antiviral immunity by exporting 2',5'-oligoadenylates (2-5A), second messengers generated by oligoadenylate synthetase upon viral dsRNA sensing 2. This export mediates intercellular propagation of antiviral signaling, activating RNase L in neighboring uninfected cells to confer viral protection 2. In cancer, ABCC10 mediates multidrug resistance by preventing intracellular accumulation of taxanes, vinca alkaloids, epothilone B, and cytarabine 13. ABCC10 also exports cGAMP in cancer cells, suppressing STING-TBK1-IRF3 signaling and contributing to radiotherapy resistance 4. ABCC10 expression is upregulated in a p53-dependent manner during DNA-damage-induced apoptosis 5. Clinically, ABCC10 inhibitors including tyrosine kinase inhibitors (imatinib, erlotinib, nilotinib) and phosphodiesterase inhibitors (sildenafil) can reverse ABCC10-mediated drug resistance 3. Additionally, ABCC10 plays roles in doxorubicin cardiotoxicity susceptibility and knee osteoarthritis pathogenesis 67.