ABHD13 encodes a palmitoyl-protein hydrolase localized to the plasma membrane 1. The protein functions in protein depalmitoylation, a post-translational modification critical for regulating protein trafficking and signaling 1. ABHD13 has emerged as a differentially expressed gene implicated in amyotrophic lateral sclerosis (ALS) pathology, associated with altered drug metabolism and AKT/mTOR signaling dysregulation 1. In pain physiology, ABHD13 knockout mice exhibit altered inflammatory pain responses, suggesting the gene participates in nociceptive pathways 2. Notably, ABHD13 maps to chromosome 13.3, a locus identified through admixture mapping as conferring reduced Alzheimer disease risk in Hispanic and Latino populations with Native American ancestry 3. Additionally, ABHD13 displays decreased DNA methylation in early-onset high myopia cases, indicating potential epigenetic dysregulation in ocular development 4. These findings position ABHD13 at the intersection of multiple neurodegenerative and sensory disorders, though mechanistic details linking depalmitoylation activity to specific disease pathways require further characterization.