ACKR2 (atypical chemokine receptor 2) is a specialized chemokine scavenger that regulates inflammatory responses by binding and degrading CC chemokines without triggering conventional G-protein signaling cascades 1. The receptor is expressed in various cell types including lymphatic endothelial cells, trophoblasts, and lung capillary endothelial cells (aerocytes) 2. ACKR2 functions by sequestering inflammatory chemokines like CCL5 and CXCL10, thereby modulating immune cell recruitment and tissue inflammation 3. In reproductive biology, ACKR2 in trophoblasts protects against inflammation-induced pregnancy complications and is essential for normal placental development and fetal survival 4. In cancer, ACKR2 exhibits context-dependent roles: it can promote tumor progression by inducing CD8+ T cell senescence in cervical cancer after chemoradiotherapy 5, facilitate lung cancer metastasis through CXCL14-dependent signaling 6, yet also suppress lung metastases by regulating T lymphocyte extravasation 2. Clinically, ACKR2 expression serves as a prognostic biomarker in various cancers, with therapeutic targeting showing promise for enhancing immunotherapy responses, particularly in 'cold' tumors resistant to immune checkpoint blockade 3.