ACP2 encodes lysosomal acid phosphatase 2, a monoesterase that hydrolyzes orthophosphoric monoesters to alcohol and phosphate within lysosomal compartments 1. The enzyme plays critical roles in lysosomal function and cellular homeostasis, with loss-of-function mutations causing lysosomal storage body accumulation and progressive cellular degeneration 2. ACP2 is essential for viral entry mechanisms, specifically required for membrane fusion during influenza virus infection, where it facilitates endosomal-viral membrane fusion and subsequent nucleocapsid uncoating 3. The protein shows dynamic developmental expression patterns, particularly in cerebellar Purkinje cells where it exhibits zonal organization associated with sensory-motor circuitry topography 1. Disease associations include neurodegeneration, with ACP2 identified as a key diagnostic marker for Parkinson's disease through machine learning approaches and showing correlation with immune infiltration patterns 4. Additionally, ACP2 variants are associated with corneal astigmatism development 5 and kidney disease susceptibility, particularly in diabetic contexts 6. The gene maps to chromosome 11-p12 [PMID:730175], and mutations result in cerebellar malformations and skin abnormalities in mouse models, highlighting its importance in tissue homeostasis 2.