ADGRG7 (adhesion G protein-coupled receptor G7), also known as GPR128 1, is an orphan adhesion GPCR characterized by G protein-coupled receptor activity and plasma membrane localization 1. As a member of the ADGRG subfamily, ADGRG7 represents an underexplored therapeutic target with emerging relevance across multiple disease contexts 2. The receptor's function remains largely undetermined, though recent evidence suggests involvement in viral infection responses; ADGRG7 mRNA expression significantly increases in SARS-CoV-2-infected lung epithelial cells, and knockdown studies demonstrate that ADGRG7 downregulation reduces viral replication and infectivity 3. ADGRG7 has been identified as a candidate disease gene in genomic studies of Mendelian disorders 4. In cancer contexts, elevated ADGRG7 expression correlates with poor clinical outcomes in both endometrial and breast cancers, suggesting potential roles in tumor development 56. Conversely, ADGRG7 is downregulated in severe periodontitis tissues compared to healthy controls, indicating tissue-specific dysregulation in inflammatory conditions 7. A rare TFG-ADGRG7 fusion has been detected in mesothelioma cases 8. Despite these emerging associations, ADGRG7's molecular mechanism and specific ligands remain largely unexplored, limiting therapeutic development.