AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1) catalyzes the acylation of lysophosphatidic acid (LPA) at the sn-2 position to generate phosphatidic acid (PA), a critical precursor for phospholipid and triacylglycerol biosynthesis 1. This enzyme localizes to the endoplasmic reticulum membrane and exhibits biochemical properties similar to its homolog AGPAT2 2. AGPAT1 serves important physiological roles across multiple organ systems; Agpat1-null mice exhibit metabolic dysfunction including hypoglycemia and reduced gluconeogenesis, reproductive abnormalities with impaired spermatogenesis and oligoanovulation, and neurological defects including audiogenic seizures and abnormal hippocampal development 1. Genetically, AGPAT1 variants are associated with exfoliation syndrome (XFS), an age-related systemic disorder affecting extracellular matrix homeostasis and causing ocular manifestations including glaucoma—the world's leading cause of irreversible blindness 345. Additionally, AGPAT1 has been identified as an endocrine-disrupting chemical-responsive gene linked to endometriosis risk through genome-wide association studies and Mendelian randomization analyses 6. Recent evidence suggests AGPAT1 serves as a colonic biomarker for discriminating ulcerative colitis with primary sclerosing cholangitis from ulcerative colitis alone 7, highlighting its potential clinical diagnostic utility in inflammatory bowel disease.