AHNAK is a large (~700 kDa) ubiquitously expressed scaffolding nucleoprotein involved in diverse cellular processes through extensive protein-protein interactions 1. Primary functions include calcium homeostasis regulation via interaction with L-type voltage-gated calcium channels in excitable cells 2, membrane repair, and cell architecture maintenance 1. AHNAK mediates DNA damage repair (DDR) pathways critical for cellular stress responses; its mRNA is stabilized by NAT10-mediated ac4C modification, and this stabilization is essential for cisplatin resistance in bladder cancer 3. The protein acts as a scaffolding component in TGF-β/Smad signaling, where it regulates epithelial-mesenchymal transition in cancer progression 4. In disease contexts, AHNAK emerges as a key driver protein in Alzheimer's disease pathogenesis within glia-neuron interaction networks 5, and its dysregulation is implicated in multiple cancer types through MAPK, ERK, Wnt, and MEK pathway activation 6. AHNAK is essential for productive infection by both influenza A and SARS-CoV-2 viruses 7, and somatic AHNAK mutations contribute to intracranial aneurysm pathogenesis via NF-κB signaling dysregulation 8. These diverse roles establish AHNAK as a multifunctional therapeutic target across neurodegeneration, oncology, and infectious disease contexts.