HNRNPH2 encodes a heterogeneous nuclear ribonucleoprotein that plays critical roles in RNA processing and neurodevelopment. As a component of hnRNP complexes, HNRNPH2 regulates RNA splicing, particularly alternative splicing, and binds G-rich RNA sequences including potential G-quadruplex structures 1. The protein functions in RNA maturation processes including 5' capping, 3' polyadenylation, and RNA export 1. HNRNPH2 also interacts with specific tRNA halves (5'-tRH-GlyGCC) that are generated during endoplasmic reticulum stress, modulating mRNA isoform biogenesis and cancer cell proliferation 2. Mutations in HNRNPH2 cause X-linked intellectual developmental disorder, Bain type, characterized by developmental delay, intellectual disability, motor disturbances, and seizures 34. The protein shows enriched expression in radial glial progenitors during cerebral cortical development, indicating its importance in neurodevelopmental processes 3. Mechanistically, HNRNPH2 regulates the alternative splicing of its homolog HNRNPH1, suggesting complex regulatory interactions between family members 5. Preclinical studies demonstrate that antisense oligonucleotide therapy targeting HNRNPH2 can rescue neurological phenotypes in mouse models, providing potential therapeutic approaches 5.