RBM12 (RNA binding motif protein 12) is a multi-functional RNA-binding protein that regulates diverse cellular processes through post-transcriptional mechanisms. The protein contains multiple RNA recognition motif (RRM) domains that enable specific RNA binding and functional interactions 12. RBM12 functions as a key regulator of alternative splicing by localizing to nuclear speckles through interactions with WAC (WW domain containing adaptor with coiled-coil), where it potentially interacts with spliceosomal components to control mitophagy through BECN1 splicing 3. The protein also serves as a translational enhancer, directly binding JAK1 mRNA via its 4th-RRM domain while recruiting translation initiation factor EIF4A2 through its 2nd-RRM domain to promote JAK1 expression and subsequent PD-L1-mediated immune evasion in hepatocellular carcinoma 2. Additionally, RBM12 acts as a negative regulator of fetal hemoglobin expression by binding preferentially to 5' untranslated regions of transcripts 1. Clinically, RBM12 is significant as a high-penetrance risk factor for familial schizophrenia and psychosis, where loss-of-function variants lead to hyperactive GPCR/cAMP/PKA signaling through altered expression of pathway effectors 45. Rare damaging variants in RBM12 are also associated with increased atherosclerotic cardiovascular disease risk 6.