AKAP5 is a multivalent scaffold protein that anchors protein kinase A (PKA) and other signaling molecules to specific subcellular locations, particularly at neuronal synapses and cardiac myocytes 1. The protein forms signaling complexes by binding PKA, calcineurin (PP2B), and G-protein-coupled receptors like β1- and β2-adrenergic receptors through multiple short linear motifs (SLiMs) 23. AKAP5 is essential for proper receptor trafficking, as demonstrated by impaired β1-adrenergic receptor recycling in AKAP5-deficient cells 3. In neurons, AKAP5 is crucial for synaptic plasticity and learning, with knockout mice showing delocalized PKA, disrupted dendritic signaling, and defects in operant learning 4. The protein also regulates vascular function by facilitating purinergic modulation of L-type calcium channels through formation of nanocomplexes containing P2Y11 receptors, adenylyl cyclase, and PKA 5. Additionally, AKAP5 enhances HERG channel regulation by anchoring PKA, which has implications for cardiac arrhythmias 6. Human genetic variation in AKAP5 (Pro100Leu polymorphism) is associated with differences in aggressive behavior and anger control, suggesting roles in emotional processing 7. The protein's ability to create dynamic, multivalent signaling platforms makes it critical for coordinating complex cellular responses.