AKAP7 (A-kinase anchoring protein 7) functions as a molecular scaffolding protein that targets cAMP-dependent protein kinase A (PKA) to specific subcellular locations, particularly the plasma membrane and cytoskeletal structures 1. The protein plays a crucial role in compartmentalizing PKA signaling through formation of signalosomes, as demonstrated by its interaction with PKA RII and other proteins like PDE3A in platelets 1. AKAP7 contains a unique 2',5'-phosphodiesterase domain that can rapidly degrade 2',5'-oligoadenylate (2-5A), similar to viral phosphodiesterases, suggesting it may represent an ancestral precursor to viral proteins that evade interferon-mediated antiviral responses 23. The protein exhibits tissue-specific functions, including regulation of epithelial sodium channels and involvement in cardiac Ca2+ handling 4. In disease contexts, AKAP7 shows clinical relevance as elevated peripheral blood expression levels serve as an early biomarker for post-stroke blood-brain barrier disruption, likely due to its role in lymphocyte adhesion 5. Additionally, AKAP7 appears to function as a tumor suppressor in bladder cancer, inhibiting cell migration and invasion 6. The protein has also been implicated in neuropsychiatric conditions, with genetic variants affecting subicular-prefrontal connectivity associated with suicidality 7.