AKNA (AT-hook transcription factor) is a multifunctional centrosomal protein encoded by a single gene on chromosome 9 that generates multiple transcript and protein isoforms through alternative splicing, promoter usage, and polyadenylation 1. Its primary function involves regulating neurogenesis through centrosomal microtubule organization. AKNA localizes to subdistal appendages of mother centrioles in neural stem cells and basal progenitors, where it promotes microtubule nucleation and growth, thereby mediating cell delamination during subventricular zone formation and regulating exit from this zone 2. This microtubule-organizing function extends to epithelial-to-mesenchymal transition in other cell types 2. AKNA also functions as a transcription factor activating CD40 and CD40L expression on lymphocytes 1, and serves as a negative regulator of inflammatory processes 3. Disease associations include primary Sjögren's syndrome, where the AKNA -1372C>A polymorphism A/A genotype increases risk 4, and knee osteoarthritis, where rs10817595 polymorphism correlates with increased susceptibility in Han Chinese populations 5. The precise mechanistic relationship between AKNA's dual roles as microtubule organizer and transcription factor remains unclear and requires further investigation.