AKTIP (AKT interacting protein) is a multifunctional protein with roles in telomere maintenance, cell division, and vesicle trafficking. As a component of the FTS/Hook/FHIP (FHF) complex, AKTIP promotes vesicle trafficking and fusion via interaction with the HOPS complex 1. AKTIP serves as a shelterin-interacting factor essential for telomere maintenance, where it facilitates telomeric DNA replication through interaction with TRF1 and TRF2, and physically associates with PCNA and RPA70 replication factors 2. During mitosis, AKTIP functions as part of the ESCRT machinery at the midbody, interacting with ESCRT I component VPS28 and facilitating recruitment of ESCRT III subunits CHMP4B and IST1 for proper cell division 3. The protein also interacts with A- and B-type lamins and localizes at the nuclear rim, playing a role in nuclear architecture and cellular senescence regulation 4. Loss of AKTIP has significant disease implications, driving tumorigenesis specifically in ERα-positive breast cancer through increased ERα protein levels and JAK2-STAT3 activation, contributing to endocrine resistance 5. Additionally, AKTIP shows altered expression in neuropsychiatric conditions, with elevated levels observed in a subgroup of schizophrenia patients with muscarinic receptor deficits 6.