Based on limited published evidence, AMDHD2 is an amidohydrolase domain-containing protein that hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate in the Neu5Gc degradation pathway 1. AMDHD2 functions as an N-acetylglucosamine deacetylase that catalyzes a reverse reaction in the hexosamine biosynthetic pathway, balancing GFPT2 activity to limit UDP-GlcNAc production in cells expressing GFPT2 1. The protein localizes to the nucleus and cytosol. Additionally, AMDHD2 exhibits sex-specific DNA methylation patterns, with significantly higher methylation in females 2.