ANAPC11 is a critical subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase 1. As a RING-H2 finger protein, ANAPC11 constitutes part of the catalytic component of APC/C and may recruit E2 ubiquitin-conjugating enzymes to the complex 1. The protein mediates ubiquitination and subsequent degradation of target proteins, including cell cycle regulators cyclin B1 and securin 2. ANAPC11 is widely expressed across human tissues with highest levels in skeletal muscle and heart, and shows diffuse cytoplasmic and nuclear localization 1. Functionally, ANAPC11 targets FOXO3 for ubiquitin-mediated degradation, leading to downregulation of cell cycle regulator p21 3. The gene demonstrates clinical significance in cancer, where elevated ANAPC11 expression correlates with advanced tumor stage, lymph node metastasis, and poor outcomes in urothelial bladder cancer patients 3. Additionally, ANAPC11 is upregulated in liver cancer through lncRNA BCAR4-miR-1261 regulatory mechanisms 4. Environmental arsenic exposure can disrupt ANAPC11 function by displacing zinc from its RING finger domain, leading to mitotic accumulation through stabilization of its ubiquitination targets 2.