CDC26 is a subunit of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls mitosis and G1 phase progression 1. CDC26 stabilizes the APC6 tetratricopeptide repeat (TPR) protein and is critical for APC/C assembly integrity 2. The APC/C catalyzes formation of Lys-11-linked polyubiquitin chains on target proteins to promote their degradation 1. CDC26 phosphorylation by LATS1/2 kinases modulates APC/C assembly and substrate ubiquitination 3. Clinically, CDC26 expression is significantly downregulated in aged oocytes compared to young oocytes, and this decline correlates with increased chr9 abnormalities and aneuploidy 4. CDC26 overexpression can partially rescue age-related oocyte maturation defects, suggesting therapeutic potential for maternal aging-related fertility decline 4. In pancreatic ductal adenocarcinoma, CDC26 promotes ferroptosis through ubiquitin-mediated degradation of SLC7A11, a ferroptosis inhibitor, while suppressing cell proliferation and invasion 5. CDC26 dysregulation has been associated with follicular lymphoma transformation and appears involved in altered cell cycle regulation pathways 6.